Z-D-aspartic acid β-tert·butyl ester monohydrate
Z-D-Asp(OtBu)-OH
CAS: 71449-08-6
Molecular Formula: C16H21NO6
Z-D-aspartic acid β-tert·butyl ester monohydrate - Names and Identifiers
| Name | Z-D-Asp(OtBu)-OH |
| Synonyms | Z-D-Asp(OtBu)-OH Z-D-Asp(Otbu)-Oh H2O Z-D-Asp(OtBu)-OH·H2O Z-D-ASPARTIC ACID-B-T BUTYLESTER Cbz-D-aspartic acid 4-tert-butyl ester Cbz-D-aspartic acid 4-tert-butyl ester hydrate Z-D-aspartic acid β-tert·butyl ester monohydrate CBZ-D-ASPARTIC ACID .BETA.-TERT-BUTYL ESTER MONOHYDRATE N-Benzyloxycarbonyl-D-aspartic acid 4-tert-butyl ester hydrate N-ALPHA-BENZYLOXYCARBONYL-D-ASPARTIC ACID BETA-T-BUTYL ESTER HYDRATE (2R)-2-benzyloxycarbonylamino-4-tert-butoxy-4-oxo-butanoic acid hydrate (R)-2-(Benzyloxycarbonylamino)-4-tert-butoxy-4-oxobutanoic acid hydrate |
| CAS | 71449-08-6 |
| InChI | InChI=1/C16H21NO6.H2O/c1-16(2,3)23-13(18)9-12(14(19)20)17-15(21)22-10-11-7-5-4-6-8-11;/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20);1H2/t12-;/m1./s1 |
Z-D-aspartic acid β-tert·butyl ester monohydrate - Physico-chemical Properties
| Molecular Formula | C16H21NO6 |
| Molar Mass | 323.34 |
| Melting Point | 56.5-57.1°C |
| Boling Point | 575.1°C at 760 mmHg |
| Flash Point | 301.6°C |
| Vapor Presure | 4.57E-14mmHg at 25°C |
| Storage Condition | Sealed in dry,2-8°C |
Z-D-aspartic acid β-tert·butyl ester monohydrate - Introduction
Z-D-Asp(OtBu)-OH (Z-D-Asp(OtBu)-OH) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White or off-white crystalline powder
-Molecular formula: C18H27NO6
-Molecular weight: 361.41g/mol
-Melting point: 80-82 degrees Celsius
-Solubility: Soluble in alcohol, ether and chlorinated hydrocarbon, slightly soluble in water
Use:
- Z-D-Asp(OtBu)-OH is commonly used as a protecting group in organic synthesis
-It can be used to synthesize complex polypeptide or lipopeptide molecules
-In drug research, it is also used as a substrate to inhibit peptidase
Preparation Method:
- Z-D-Asp(OtBu)-OH can be prepared by the following steps:
1. D-aspartic acid tert-butyl ester was prepared by reacting D-aspartic acid with tert-butyl alcohol ester and dimethylformamide (DMF) at low temperature
2. D-aspartic acid tert-butyl ester was reacted with benzyl chloro chloride to obtain Cbz-D-aspartic acid tert-butyl ester
3. Finally, Cbz-D-aspartic acid tert-butyl ester was hydrolyzed to obtain Z-D-Asp(OtBu)-OH
Safety Information:
-Follow laboratory safety practices when using or handling the compound
- Z-D-Asp(OtBu)-OH has no apparent toxicity or danger under normal use
-However, in the event of accidental application or contact with skin or eyes, seek medical attention immediately and bring details of the compound with you
-The compound should be stored in a dry, cool place, away from fire and oxidizing agents
Nature:
-Appearance: White or off-white crystalline powder
-Molecular formula: C18H27NO6
-Molecular weight: 361.41g/mol
-Melting point: 80-82 degrees Celsius
-Solubility: Soluble in alcohol, ether and chlorinated hydrocarbon, slightly soluble in water
Use:
- Z-D-Asp(OtBu)-OH is commonly used as a protecting group in organic synthesis
-It can be used to synthesize complex polypeptide or lipopeptide molecules
-In drug research, it is also used as a substrate to inhibit peptidase
Preparation Method:
- Z-D-Asp(OtBu)-OH can be prepared by the following steps:
1. D-aspartic acid tert-butyl ester was prepared by reacting D-aspartic acid with tert-butyl alcohol ester and dimethylformamide (DMF) at low temperature
2. D-aspartic acid tert-butyl ester was reacted with benzyl chloro chloride to obtain Cbz-D-aspartic acid tert-butyl ester
3. Finally, Cbz-D-aspartic acid tert-butyl ester was hydrolyzed to obtain Z-D-Asp(OtBu)-OH
Safety Information:
-Follow laboratory safety practices when using or handling the compound
- Z-D-Asp(OtBu)-OH has no apparent toxicity or danger under normal use
-However, in the event of accidental application or contact with skin or eyes, seek medical attention immediately and bring details of the compound with you
-The compound should be stored in a dry, cool place, away from fire and oxidizing agents
Last Update：2024-04-09 21:00:56
